A Molecular Mechanism for Lps Protection of Gram-negative Bacteria from Antimicrobial Peptides
نویسندگان
چکیده
A MOLECULAR MECHANISM FOR LPS PROTECTION OF GRAM-NEGATIVE BACTERIA FROM ANTIMICROBIAL PEPTIDES Niv Papo and Yechiel Shai* Department of Biological Chemistry. The Weizmann Institute of Science Rehovot, 76100 Israel. Running title: Bacterial Susceptibility and LPS Permeability of Peptide Diastereomers Addresse correspondence to Yechiel Shai, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel. Tel: 972-8-9342711; Fax: 972-8-9344112, e-mail: [email protected]
منابع مشابه
De novo design of potent antimicrobial peptides.
Lipopolysaccharide (LPS), shed by gram-negative bacteria during infection and antimicrobial therapy, may lead to lethal endotoxic shock syndrome. A rational design strategy based on the presumed mechanism of antibacterial effect was adopted to design cationic antimicrobial peptides capable of binding to LPS through tandemly repeated sequences of alternating cationic and nonpolar residues. The p...
متن کاملStructures of β-hairpin antimicrobial protegrin peptides in lipopolysaccharide membranes: mechanism of gram selectivity obtained from solid-state nuclear magnetic resonance.
The structural basis for the gram selectivity of two disulfide-bonded β-hairpin antimicrobial peptides (AMPs) is investigated using solid-state nuclear magnetic resonance (NMR) spectroscopy. The hexa-arginine PG-1 exhibits potent activities against both gram-positive and gram-negative bacteria, while a mutant of PG-1 with only three cationic residues maintains gram-positive activity but is 30-f...
متن کاملAntiendotoxin activity of cationic peptide antimicrobial agents.
The endotoxin from gram-negative bacteria consists of a molecule lipopolysaccharide (LPS) which can be shed by bacteria during antimicrobial therapy. A resulting syndrome, endotoxic shock, is a leading cause of death in the developed world. Thus, there is great interest in the development of antimicrobial agents which can reverse rather than promote sepsis, especially given the recent disappoin...
متن کاملمعرفی پپتید ضدمیکروبی جدید با نام Buforin–K از ترشحات پوستی وزغ کویری بومی یزد
Introduction: Today, research in the field of antimicrobial peptides is active. Thus, the aim of this study is to purify and determine biochemical properties (especially antimicrobial effect) of new antimicrobial peptides from skin secretions of bufo kavirensis. Methods: This is a descriptive study. The skin secretions of bufo was purified by biochemical manners and antimicrobial effects was ...
متن کاملTitle Resurrecting Inactive Antimicrobial Peptides from the Lipopolysaccharide Trap Resurrecting Inactive Antimicrobial Peptides from Lipopolysaccharide (lps) Trap Singapore 637551, Singapore
26 Host defense antimicrobial peptides (AMPs) are a promising source of antibiotics for the 27 treatment of multiple drug-resistant pathogens. Lipopolysaccharide (LPS), the major 28 component of the outer leaflet of the outer membrane of Gram-negative bacteria, functions as 29 a permeability barrier against a variety of molecules including antimicrobial peptides (AMPs). 30 Further, LPS or endot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2004